As college students Jake and Jan struggle to stay afloat in the current economic climate, a lucrative business opportunity presents itself through their angel investor and landlord, George. After an unfortunate series of events, the deal suddenly falls apart, and the couple, now further in debt, takes drastic measures to eliminate George to collect a large sum of money. But things do not always go to plan and after numerous failed attempts to wipe out their intended target, the couple goes on the run with George in close pursuit to even the score.

After a night of heavy drinking, Jeanne and Deb take an empty road through the backwoods to avoid traffic where they unexpectedly hit a mysterious woman that quickly vanishes into a field. Plagued with guilt and unable to go to the police, the girls decide to investigate with the help of some friends. But when their peers start to die or inexplicably vanish, it becomes clear that a bigger, sinister force is at work as Jeanne is thrown into a bizarre conflict with the undead and a sinister voodoo priest with malicious intentions.

A cult of revolutionaries plot to murder the president of a pharmaceutical conglomerate.