Lose Your Head is a psycho thriller about a Spanish party tourist who gets lost in Berlin. The film is inspired by the true story of a young Portuguese man who disappeared some years ago after a night at Berghain.

Painter Francisco Goya faces a scandal involving his muse, who is labeled a heretic by a monk.

After losing his father, 10-year-old Carlos arrives at the Santa Lucia School, which shelters orphans of the Republican militia and politicians, and is taken in by the steely headmistress, Carmen, and the kindly professor, Casares. Soon after his arrival, Carlos has a run-in with the violent caretaker, Jacinto. Gradually, Carlos uncovers the secrets of the school, including the youthful ghost that wanders the grounds.