Childhood friends Tetsuo and Kaneda are pulled into the post-apocalyptic underworld of Neo-Tokyo and forced to fight for their very survival. Kaneda is a bike gang leader, and Tetsuo is a member of a tough motorcycle crew who becomes involved in a covert government project called Akira. But a bloody battle ensues when Kaneda sets out to save his friend.

In a far-future time ruled by the supernatural, a young girl requests the help of a vampire hunter to kill the vampire who has bitten her and thus prevent her from becoming a vampire herself.