Delivery tells the story of Kyle and Rachel Massy, a young couple who agree to document their first pregnancy for a family-oriented reality show. The production spirals out-of-control after the cameras capture a series of unexplained events, leading Rachel to believe that a malevolent spirit has possessed their unborn child.

Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.