Topper is once again tormented by a fun-loving spirit. This time, it’s Gail Richards, who was accidentally murdered while vacationing at the home of her wealthy friend, Ann Carrington (Landis), the intended victim. With Topper’s help, Gail sets out to find her killer with the expected zany results.

Boston pharmacist Tom Craig comes to Sacramento, where he runs afoul of local political boss Britt Dawson, who exacts protection payment from the citizenry. Dawson frames Craig with poisoned medicine, but Craig redeems himself during a Gold Rush epidemic.

Bessie and Winston “Slug” Winters are married coaches whose mission is to whip their college football team into shape. Just in time, they discover a hillbilly farmhand and his sister. But the hillbilly farmhand’s ability to throw melons enables him to become their star passing ace.

School girl Annabel is hassled by her mother, and Mrs. Andrews is annoyed with her daughter, Annabel. They both think that the other has an easy life. On a normal Friday morning, both complain about each other and wish they could have the easy life of their daughter/mother for just one day and their wishes come true as a bit of magic puts Annabel in Mrs. Andrews’ body and vice versa. They both have a Freaky Friday.

A young couple moves into an infamous New York apartment building to start a family. Things become frightening as Rosemary begins to suspect her unborn baby isn’t safe around their strange neighbors.