Supervillains Harley Quinn, Bloodsport, Peacemaker and a collection of nutty cons at Belle Reve prison join the super-secret, super-shady Task Force X as they are dropped off at the remote, enemy-infused island of Corto Maltese.

Light years from Earth, 26 years after being abducted, Peter Quill finds himself the prime target of a manhunt after discovering an orb wanted by Ronan the Accuser.

The film is composed of multiple comedy shorts presented through an overarching segment titled “The Pitch”, in which Charlie Wessler, a mad screenwriter, is attempting to pitch a script to film executive Griffin Schraeder. After revealing several of the stories in his script, Wessler becomes agitated when Schraeder dismisses his outrageous ideas, and he pulls a gun on him and forces him to listen to multiple other stories before making Schraeder consult his manager, Bob Mone, to purchase the film.

After his wife falls under the influence of a drug dealer, an everyday guy transforms himself into Crimson Bolt, a superhero with the best intentions, though he lacks for heroic skills.

A small town is taken over by an alien plague, turning residents into zombies and all forms of mutant monsters.

The Guardians must fight to keep their newfound family together as they unravel the mysteries of Peter Quill’s true parentage.