Mexico City, November 1901. The police raid a private home where a secret party is being held. Among those attending is the son-in-law of President Porfirio Díaz.

The First Lady of Mexico has big plans to improve conditions for the country. As she starts to lose faith in her husband, President Diego Nava, she finds herself at a crossroad where she will need to find a way to deal with a great challenge.

Three different people in Mexico City are catapulted into dramatic and unforeseen circumstances in the wake of a terrible car crash: a young punk stumbles into the sinister underground world of dog fighting; an injured supermodel’s designer pooch disappears into the apartment’s floorboards; and an ex-radical turned hit man rescues a gunshot Rotweiler.

Jeremy Irons plays a Spanish Jesuit who goes into the South American wilderness to build a mission in the hope of converting the Indians of the region. Robert DeNiro plays a slave hunter who is converted and joins Irons in his mission. When Spain sells the colony to Portugal, they are forced to defend all they have built against the Portugese aggressors.