Milan, Italy, 1967. Santo Russo, a boy of Calabrian origin, arrives north with his parents and younger brother to find better living conditions. Due to an absurd misunderstanding and his father’s contempt, Santo ends up in prison, where he gets a “true education.” In 1978, he and his friends Slim and Mario embark on a 15-year criminal career, a successful and ruthless spiral of robberies, kidnappings, murders and heroin smuggling.

Just out of prison, ex-con Ugo Piazza meets his former employer, a psychopathic gangster Rocco who enjoys sick violence and torture. Both the gangsters and the police believe Ugo has hidden $300,000 that should have gone to an American drug syndicate boss.