Doom: Annihilation follows a group of space marines as they respond to a distress call from a base on a Martian moon, only to discover it’s been overrun by demonic creatures who threaten to create Hell on Earth.

On the cusp of 19th century in Delhi, we following the fortunes of the residents of the titular mansion. The story begins as handsome and soulful former English soldier, John Beecham, has acquired the house to start a new life for his family and a business as a trader.

Gary Faulkner (Cage) is an ex-con, unemployed handyman, and modern day Don Quixote who receives a vision from God (Brand) telling him to capture Osama Bin Laden. Armed with only a single sword purchased from a home-shopping network, Gary travels to Pakistan to complete his mission. While on his quest, Gary encounters old friends back home in Colorado, the new friends he makes in Pakistan, the enemies he makes at the CIA – and even God and Osama themselves.