When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.

Brantley Foster, a well-educated kid from Kansas, has always dreamed of making it big in New York, but once in New York, he learns that jobs – and girls – are hard to get. When Brantley visits his uncle, Howard Prescott, who runs a multi-million-dollar company, he is given a job in the company’s mail room.