A group of friends is stalked by a killer at an isolated destination wedding.

Mary Ann returns to present-day San Francisco and is reunited with her daughter and ex-husband, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal, her chosen family and a new generation of queer young residents living at 28 Barbary Lane.