A reality TV program selects six contestants to participate in a free-for-all, no holds barred deathmatch, where they must skillfully outwit and kill each other in order to be the last person alive.

Christmas Eve in New York, and the lonely divorced publisher, Rose Collins, needs a miracle to improve the health of her mother, interned in a hospital with Alzheimers. She feels sorry for another patient and meets his visitor. Meanwhile, Nina Vasquez breaks her engagement with her beloved fiancé Mike due to his suffocating jealousy, but misses him. Mike is stalked by a stranger, bartender Artie Venzuela. The poor Jules arranges to spend Christmas Eve in the hospital, where he spent the best Christmas of his life when he was a teenager. The lives of some of these characters cross with others along the night.

Larry Flynt is the hedonistically obnoxious, but indomitable, publisher of Hustler magazine. The film recounts his struggle to make an honest living publishing his girlie magazine and how it changes into a battle to protect the freedom of speech for all people.