The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman’s thin and obnoxious alter ego, Buddy Love, wants out…and a big piece of the action. And when Buddy gets loose, things get seriously nutty.

Martin Blank is a freelance hitman who starts to develop a conscience, which causes him to muff a couple of routine assignments. On the advice of his secretary and his psychiatrist, he attends his 10th year High School reunion in Grosse Pointe, Michigan.