A vampire awakens from a long sleep to attack a couple making love in a graveyard. He then rapes the woman, who later gives birth to his son. The newborn infant will only drink blood from his mother’s breast.

After a dying Voodoo queen chooses an adopted apprentice as her successor, her true heir is outraged. Seeking revenge, he buys the bones of Blacula the vampire off of a dealer, and uses voodoo to bring the vampire back to do his bidding. In turn, Blacula turns him into a vampire and makes him his slave. Meanwhile, a police officer with a large collection of African antiques and an interest in the occult investigates the murders caused by Blacula and his vampire horde.