Not only is Jessica Spencer (Rachel McAdams) the most popular girl in school — she is also the meanest. But things change for the attractive teen when a freak accident involving a cursed pair of earrings and a chance encounter at a gas station causes her to switch bodies with Clive (Rob Schneider), a sleazy crook. Jessica, in the form of the repulsive Clive, struggles to adjust to this radical alteration and sets out to get her own body back before the upcoming prom.

The Candyman moves on to New Orleans and starts his horrific murders once more. This time, his intended victim is a school teacher. Her father was killed by the Candyman, and brother wrongly accused of the murders.