A hospital nurse is possessed by an evil spirit, and proceeds to kill off the hospital’s patients.

Fearful that their star witness might be murdered, two attorneys hire a protector to bring him from Los Angeles to New York. Jesse Crowder (Fred Williamson) is a no-nonsense tough guy. He buddies up with the witness, an accountant, and they hit the road. Outwitting their foes means taking all manner of conveyance, including automobile, train, and airplane.