In 1916, beautiful young mute Helen is a domestic worker for elderly, ailing Mrs. Warren. Mrs. Warren’s two adult sons, Albert (a professor) and womanizing impudent Steven, also live in the Warren mansion. Mrs. Warren becomes concerned for Helen’s safety when a rash of murders involving ‘women with afflictions’ hits the neighborhood. She implores her physician, Dr. Parry, to take Helen away for her own safety. When another murder occurs inside the Warren mansion, it becomes obvious that Helen is in danger.
The greedy nephew of eccentric Matilda Reid seeks to have her judged incompetent so he can administer her wealth; but she will be saved if her three long-lost adopted sons appear for a Christmas Eve reunion. Separate stories reveal Michael as a bankrupt playboy loved by loyal Ann; Mario as a seemingly shady character tangling with a Nazi war criminal in South America; Jonathan as a hard-drinking rodeo rider intent on a flirtatious social worker. Is there hope for Matilda?
Judith Traherne is at the height of young society when Dr. Frederick Steele diagnoses a brain tumor. After surgery she falls in love with Steele. The doctor tells her secretary that the tumor will come back and eventually kill her. Learning this, Judith becomes manic and depressive. Her horse trainer Michael, who loves her, tells her to get as much out of life as she can. She marries Steele who intends to find a cure for her illness. As he goes off to a conference in New York failing eyesight indicates to Judith that she is dying.