When shark conservationist Dr. Misty Calhoun is invited to consult on a top-secret project run by pharmaceutical billionaire Carl Durant, she is shocked to learn that the company is using unpredictable and highly aggressive bull sharks as its test subjects, which soon break loose and cause havoc.

Over a series of video chats, a teenage outcast reaches out to his childhood friend, but finds that behind the veneer of popularity and a seemingly perfect life, she hides a disturbing secret.