Two hapless frieght handlers find themselves encountering Dracula, the Frankenstein Monster and the Wolf Man.

The Wrecker wrecks trains on the L & R Railroad. One of his victims is Larry Baker’s father. Baker wants to find the evildoer, among a host of suspects, but it will be difficult since the Wrecker can disguise himself to look like almost anyone

A scientist working on cures for rare afflictions, such as a bone softening agent made from molds to allow him to correct the spinal deformity of his nurse, finds the physical causes of lycanthropy in wolf-man Larry Talbot and of vampirism in Count Dracula, but himself becomes afflicted with homicidal madness while exchanging blood with Dracula.