Charlie Gordon is mentally handicapped and all he wants in life is to be a genius. When he gets picked for experimental surgery it looks like his dream may finally come true. But the surgery has side effects that could could kill Charlie. Can Charlie survive being just plain old “Charlie Gordon” and will his newfound romance survive this test of character?

Elwood, the now lone “Blues Brother” finally released from prison, is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children’s hospital. Once again hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops, led by Cabel the Curtis’ son