In the near future, a virus has infected everyone on the planet, and Absolon is a drug that everyone must take to stay alive. One corporation controls the drug. Murchison is the leader of this firm. A scientist who was researching the virus is found murdered, and Norman Scott is the policeman who investigates the crime.

Cady Heron is a hit with The Plastics, the A-list girl clique at her new school, until she makes the mistake of falling for Aaron Samuels, the ex-boyfriend of alpha Plastic Regina George.