“Six Flying Dragons” is a Period drama depicts the ambitions and success stories of 6 people around Prince Lee Bang Won. This drama also depicts the ideological and political conflict between Prince Lee Bang Won and Jung Do Jeon who is the man instrumental in helping King Taejo to establish the fledgling Joseon nation. Jung Do Jeon wants a country ruled by ministers, while Lee Bang Won wants absolute power. Prince Lee Bang Won later become King TaeJong who was the third king in the Joseon Dynasty. He helped his father King Taejo to establish the Joseon Dynasty.

University students Yoon Jin-Myung, Jung Ye-Eun, Song Ji-Won, Kang Yi-Na and Yoo Eun-Jae share a house. Jin-Myung is busy supporting herself financially and studying. She suffers from lack of sleep. Ye-Eun is devoted to her boyfriend, she is clear about what she likes or not. Ji-Won has a bright personality and likes to drink. Yi-Na is popular due to her beautiful appearance. Eun-Jae is timid, but she has an unique taste for men.