Four characters wake in a desert, disoriented and lost with no clue where they are or how they got there.

Deuce Bigalow goes to Amsterdam after a little accident including two irritating kids and a bunch of aggressive dolphins. There he meets up with his old friend T.J. Hicks. But a mysterious killer starts killing some of Amsterdam’s finest gigolos and T.J. is mistaken for the extremely gay murderer. Deuce must enter the gigolo industry again to find the real murderer and clear T.J.’s name.