Jae-hyuk is a pharmaceutical worker for a medical supplies company. When a series of dead bodies are found floating in the Han River. The public is shocked to discovered that the deaths are related to a fatal outbreak of virus-infected mutant parasitic horsehair worms, called ‘Yeongasi’, that can control the human brain. Those infected shows symptoms of hunger and thirst, hence jumps into the river to combat dehydration. Whilst the authorities work to find a cure, Jae-hyuk struggles to save his family when they also exhibits similar symptoms.

A con man who had been reported dead after committing a historical fraud case is rumored to be alive. Prosecutor Park who was in collusion with the con man needs to eliminate him to avoid a corruption scandal. During his pursuit of the con man, he meets Ji-sung who is also after the same man for a personal revenge. Realizing their mutual goals, they decide to team up, but with hidden motives.

In the 11th year of Kwang Hae-gun, Jo-seon soldiers go to war with China after an invasion. In the middle of Manchu, three people who have barely survived are being cornered by the Chinese forces, and begin a bloody battle not with their enemies but with their friends.

A detective infiltrates into one of the biggest gang organizations in the country and gets involved in a fight for the heir to the gang after the boss dies and in between the second in charge who trusts him with his life and the high police officials who think of him only as bait.