Cassidy is a senior at a NYC college and he’s trying to balance the demands of school, his role as big brother to Jessica, a freshman at the same school and his role as best buddy to horn-dog Mike with his emerging feelings of attraction to men. This is further complicated by a string of co-ed murders on campus for which his sister fits the victim profile.

Carol Ann MacKay is a popular nurse at a retirement home, and spends her free time with her hunky athletic husband Wayne MacKay, who would do anything for her, including cleaning up the messes her ideas get them in. When legendary bank robber Henry Manning, who had a major stroke in prison, is placed in the home and supposedly having lost all control over his body, she notices he must be in far better condition then he lets appear. Soon Carol gets his confidence and the two start planning how they three can commit another robbery on an armored money transport.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth’s population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he’s arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly, and patient Jeffrey Goines, the son of a famous virus expert, who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease.