Elwood, the now lone “Blues Brother” finally released from prison, is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children’s hospital. Once again hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops, led by Cabel the Curtis’ son

During a championship baseball match, the three brothers hear that their grandfather in Japan is in trouble, and head out to help him, conceding the match. When they arrive in Japan, they must use all their powers to defend him against his ancient enemy, who has returned to exact revenge.