Dr. Alvaro Cruz, a neuroscientist, disillusioned by the death of his mother and his inability to help her, finds redemption and reward by helping Una Vida, a jazz singer he discovers performing on the streets of New Orleans. Her health declining and her singing partner and her adopted daughter unable to help, Cruz seeks out her long lost son in an effort to bring resolution to the grief, loss and longing that has overshadowed her hard but beautiful life.

An African-American woman becomes an unwitting pioneer for medical breakthroughs when her cells are used to create the first immortal human cell line in the early 1950s.