A small but growing Texas town, filled with strange and musical characters, celebrates its sesquicentennial and converge on a local parade and talent show.

Thirty years after separating when their friendship is harmed by a mutual love of the same woman, two friends, Bobby Ray and Pal, return to their hometown to settle old debts.

When three women living on the edge of the American frontier are driven mad by harsh pioneer life, the task of saving them falls to the pious, independent-minded Mary Bee Cuddy. Transporting the women by covered wagon to Iowa, she soon realizes just how daunting the journey will be, and employs a low-life drifter, George Briggs, to join her. The unlikely pair and the three women head east, where a waiting minister and his wife have offered to take the women in. But the group first must traverse the harsh Nebraska Territories marked by stark beauty, psychological peril and constant threat.

Amidst her own personality crisis, southern housewife Evelyn Couch meets Ninny, an outgoing old woman who tells her the story of Idgie Threadgoode and Ruth Jamison, two young women who experienced hardships and love in Whistle Stop, Alabama in the 1920s.