Drake and Josh are left home alone while their mom and dad leave on a ten-day cruise. But they have to take Megan to the airport in order to be ‘entirely’ left alone. Megan has to go to Colorado to meet her. Drake gets her a ticket to go not to Colorado, but to Los Angeles. Drake and Josh try to stop the plane, but are stopped by security guards. Then, they buy tickets to go to LA. When they’re on the plane, Drake sits next to some cute girls, while Josh sits next to some very annoying people. In the middle of the flight, Josh decides to go to a different seat. Josh sits next to a man that has a G-0. He doesn’t notice that the G-0 contains codes to run the money machine that he saw on the news. The annoying lady walks up to the front near Josh while there is turbulence. The lady falls on Josh, mixing up the G-0’s.

Fast-talking Latino con artist Pestario “Pest” Vargas is the target of Scottish mobsters to whom he owes a considerable debt. Willing to do anything to raise money and avoid severe injury or death, Vargas agrees to a very unusual job — he will be transported to a remote island and hunted by Gustav Shank, a racist German executive. If he can survive a full day and night, Vargas gets $50,000 and will be set free. Is he wily enough to elude Shank?