A successful physician and devoted family man, John Dolittle (Eddie Murphy) seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor’s advice, unleashing an outrageous chain of events that turns his world upside down!

Novelist Paul Sheldon crashes his car on a snowy Colorado road. He is found by Annie Wilkes, the “number one fan” of Paul’s heroine Misery Chastaine. Annie is also somewhat unstable, and Paul finds himself crippled, drugged and at her mercy.