U.S. federal agent Leon S. Kennedy sneaks into the “East Slavic Republic” to verify rumors that Bio-Organic Weapons (BOWs) are being used in the country’s civil war, which the U.S. and Russia are making preparations to jointly intervene in. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the BOWs.

Hunted by the Ming from China, young Kotaro and his dog meet a nameless samurai “Nanashi” who is haunted constantly by memories of his past which has led him to avoid drawing his sword ever again. Among the Ming is a fearsome Western fighter named Raro, whose only desire is to find a worthy opponent.