The adventures of 13-year-old, self-centered Anne Boonchuy who is magically transported to the fictitious world of Amphibia, a rural marshland full of frog-people. With the help of an excitable young frog named Sprig, Anne will transform into a hero and discover the first true friendship of her life.

In 2100, when humanity has abandoned the earth, a colony of extravagant creatures still thrives in the deepest abyss of the ocean.