Michel, a murderous womanizer, meets introverted Gloria online and treats her to a whirlwind one-night-stand. Offering herself as an accomplice in his seductive crimes, the unhinged lovers embark on a deadly odyssey amplified by wild sex, unbridled jealousy, and passionate forays into the dark arts. This smart and gory shocker breathes new life into the lovesick horror genre to serve up a chilling tale of white-hot desperation and terrifying devotion.

Raimunda (Penélope Cruz) works and lives Madrid with her husband Paco and daughter Paula. Her sister Sole (Lola Dueñas) lives nearby and they both miss their mother Irene (Carmen Maura), who died several years ago in a house fire along with their father. A former neighbor from their hometown reports that she has seen the ghost of Irene and both daughters do not believe her. After a murder and a family tragedy, Irene’s spirit materializes around her daughters to help comfort them.

Two men share an odd friendship while they care for two women who are both in deep comas.