A scientist, Dr Holander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.

Three college students, Phil, Ed, and Henry take a road trip into Mexico for a week of drinking and carefree fun only to have Phil find himself a captive of a group of satanic Mexican drug smugglers who kill tourists and whom are looking for a group of new ones to prepare for a sacrifice.