The humans and animals believe a werewolf is on the loose, and former hunter Shaw uses the opportunity to re-open the season. Boog, Elliot, and Mr. Weenie have to face their fears and find the werewolf to get the season closed permanently.

Boog, a domesticated 900lb. Grizzly bear finds himself stranded in the woods 3 days before Open Season. Forced to rely on Elliot, a fast-talking mule deer, the two form an unlikely friendship and must quickly rally other forest animals if they are to form a rag-tag army against the hunters.