While serving time for insanity at a state mental hospital, implacable rabble-rouser, Randle Patrick McMurphy inspires his fellow patients to rebel against the authoritarian rule of head nurse, Mildred Ratched.

Coffy is a nurse whose younger sister gets involved in drugs and is severely injured by contaminated heroin. Coffy sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path.