009 Re:Cyborg follows a group of nine cyborgs, each of them created by a shadowy organization for use as weapons against humanity. The group turns on their creators to protect the population instead, using the powers given them to fight their creators.

In the massive city of Tokyo, Kumiko, a twenty-nine year old, lives in utter solitude. She works a dreadful, dead-end job under an awful boss, is intimidated by her well-off peers, and nagged incessantly by her overbearing mother who is exasperated by the fact that her daughter is not married or even in a relationship. The only joys in her life come from a grainy VHS tape – an American film in which a man buries a satchel of money in the snowy Midwestern plains – and her beloved pet rabbit, Bunzo. Kumiko is somehow convinced that this treasure is real, and obsesses over its discovery. With a hand-stitched treasure map and a quixotic spirit, Kumiko embarks on an incredible journey over the Pacific and through the frozen Minnesota wilderness to uncover a purported fortune.

Guts, an immensely strong sword-for-hire, has little direction in his life, simply fighting one battle after the next. However, this all changes suddenly when he meets and is bested by Griffith, a beautiful and charismatic young man who leads the Band of the Hawk mercenary army. After Guts joins the Band and the relationship between the two men begins to blossom, Casca, the tough, lone swordswoman in the Band of the Hawk, struggles to accept Guts and the influence he has on the world around her. While the two men begin to fight together, Griffith continues to rise to power, all seemingly in order to reach his mysterious, prophesied goals. What lengths will Guts and Griffith go to in order to reach these goals, and where will fate take the two men?