George Jetson is forced to uproot his family when Mr. Spacely promotes him to take charge of a new factory on a distant planet.

Kronk, now chef and Head Delivery Boy of Mudka’s Meat Hut, is fretting over the upcoming visit of his father. Kronk’s father always disapproved of young Kronk’s culinary interests and wished that Kronk instead would settle down with a wife and a large house on a hill.

Kuzco is a self-centered emperor who summons Pacha from a village and to tell him that his home will be destroyed to make room for Kuzco’s new summer home. Kuzco’s advisor, Yzma, tries to poison Kuzco and accidentally turns him into a llama, who accidentally ends up in Pacha’s village. Pacha offers to help Kuzco if he doesn’t destroy his house, and so they form an unlikely partnership.