(William H. Macy) works at a Las Vegas casino, where he uses his innate ability to bring about misfortune in those around him to jinx gamblers into losing. His imposing boss, Shelly Kaplow (Alec Baldwin), is happy with the arrangement. But Bernie finds unexpected happiness when he begins dating attractive waitress Natalie Belisario (Maria Bello).

The Russians need help in dealing with the Mafia and so they seek help with the veterans of the Police Academy. They head off to Moscow, in order to find evidence against Konstantin Konali, who marketed a computer game that everyone in the world is playing.

The nerds are now in control of the university, as a result of Lewis Skolnick and the rest’s actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won’t reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.