Soul-touching and moving, TWO WAYS HOME compassionately follows Kathy (Tanna Frederick), a woman newly diagnosed with bipolar disorder who is released from prison on good behavior and returns to her country home in Iowa to reconnect with her estranged 12-year-old daughter (Rylie Behr) and her cantankerous elderly grandfather (Tom Bower). Her return home is turbulent and a rough, unwelcome transition in which Kathy must come to terms with her diagnosis and its implications on her identity, while also realizing that her family was happier when she was gone. Conflict with her family intensifies as she struggles to keep her head above water, putting her self-worth and well-being to the ultimate test.

At the end of the Civil War, Frank and Jesse James and other former guerillas who rode with Quantrill and Bill Anderson take the oath of allegiance to the Union. Feeling oppressed by Chicago railroad investors, the James and Younger brothers, Bob and Charlie Ford, Clell Miller and Arch Clements take to robbing banks, trains and coaches, with Pinkerton sworn to bringing them to justice.