A time bomb is ticking in a small regional postal facility and his name is Oren Starks (Brad Garrett). Oren fits the profile of a new breed of killers – postal workers who crack under pressure. Their brains short circuit and the paranoid delusions begin. Going Postal begins as famed psychologist Dr. Nicolas Brink (Richard Portnow) launches his controversial research study in order to create a “psychological vaccine” to defuse these human time bombs who seem to be going postal at an alarming rate. It is revealed that almost everyone at this post office is on the brink of insanity! There’s a perverse love triangle involving Oren, Harry Cash (Rob Roy Fitzgerald) and the sexy survivor of another postal shootout, Tammy Skye (Grace Cavanaugh). Postmaster Calhoun (William Long, Jr.) is driving the staff nuts by constantly micro monitoring their bathroom breaks. Something has got to give and its not the timely delivery of the U.S. mail.

Film cutter Katie Griffin is hopelessly in love with writer Richard Mannhart, and starts an affair with him. When Mannhart’s wife is killed in a road accident, Katie tells the police she thinks he’s tampered with his wife’s car. Being questioned Mannhart declares he’s innocent. Not only that, he also denies any amorous involvement with Griffin. As it is her word against his, both parties are pressed to back up their stories with hard evidence. Finally Katie comes up with some. End of story?

Three assassins deal with life, love, addiction and trust as each tries to find the answers to a better life. Together, they prove to be the most trustworthy in this tangled web of murder, greed, friendship and betrayal.