Real estate agent Maceda (Chris Sarandon) once testified against drug trafficker Orosco (Miguel Najera). Now Orosco is out of prison, and Maceda has a problem. He flees, hiding out at a near-vacant California Central Valley inn where innkeeper Kat (Mariel Hemingway) is happy to have him sign the register. His presence, however, arouses the suspicions of lone cop Gilchrist (Dennis Hopper). Meanwhile, Fed agent Gere (Peter Coyote) hopes to track Maceda before Orosco’s thugs pick up the scent.

Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.

A group of men who were clearing bush for the government arrive back in town, claiming that their friend was abducted by aliens. Nobody believes them, and despite a lack of motive and no evidence of foul play, their friends’ disappearance is treated as murder.