Every day is a matter of life and death in a hectic New York City hospital, but for Nurse Jackie that’s the easiest part. Between chronic back pain that won’t quit, and a personal life on the constant edge of collapse, it’s going to take a white lie here, a bent rule there, and a handful of secret strategies to relieve the pain, and stay one step ahead of total disaster.

Three years after his wife, acclaimed photographer Isabelle Reed, dies in a car crash, Gene keeps everyday life going with his shy teenage son, Conrad. A planned exhibition of Isabelle’s photographs prompts Gene’s older son, Jonah, to return to the house he grew up in – and for the first time in a very long time, the father and the two brothers are living under the same roof.

Still reeling from a heartbreaking family event and his parents’ subsequent divorce, Tyler Hawkins discovers a fresh lease on life when he meets Ally Craig, a gregarious beauty who witnessed her mother’s death. But as the couple draws closer, the fallout from their separate tragedies jeopardizes their love.