The central premise of Being Human is that various types of supernatural beings exist alongside human beings, with varying degrees of menace; that three of these supernatural beings are opting to live amongst human beings rather than apart from them; and that these three characters are attempting (as much as is possible) to live ordinary human lives despite the pressures and dangers of their situations. They are constantly threatened with exposure or persecution, with pressure from other supernatural creatures, and with problems caused by their attempts to deal with their own natures.

Three paranormal roommates, a ghost, a vampire, and a werewolf, struggle to keep their dark secrets from the world, while helping each other navigate the complexities of living double lives.