The film tells the tale of a widowed film director who is in the middle of making a film about an atypical diplomat inspired by his brother. While he has started a new life with Sylvia, he still mourns the death of a former lover, Carlotta, who passed away 20 years earlier; then Carlotta returns from the dead, causing Sylvia to run away.

Paul is preparing to leave Tajikistan, while thinking back on his adolescent years. His childhood, his mother’s madness, the parties, the trip to the USSR where he lost his virginity, the friend who betrayed him and the love of his life.

Adapted from the 1951 non-fiction account by psychoanalyst Georges Devereux, “Psychotherapy Of A Plains Indian,” the film follows the true story of Picard (Del Toro), a Plains Indian of the Blackfeet nation, as he returns from WWII and begins experiencing unexplainable symptoms shortly thereafter. He travels to the famous Winter Hospital in Topeka, Kansas, where he meets Devereux (Amalric), thus beginning a professional and personal friendship guided by compassion and understanding of Native American culture.

When their regal matriarch falls ill, the troubled Vuillard family come together for a hesitant Christmastime reunion. Among them is rebellious ne’er-do-well Henri and the uptight Elizabeth. Together under the same roof for the first time in many years, their intricate, long denied resentments and yearnings emerge again.