After the 1860s Wild West, a group of misfit settlers – including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian – decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.

U.S. Marshall John Kruger erases the identities of people enrolled in the Witness Protection Program. His current assignment is to protect Lee Cullen, who’s uncovered evidence that the weapons manufacturer she works for has been selling to terrorist groups. When Kruger discovers that there’s a corrupt agent within the program, he must guard his own life while trying to protect Lee’s.