The Los Angeles club scene is a place of booze-fueled decadence and debauchery. In a night full of possibilities, eight 20-somethings take to the clubs seeking good times, companionship and maybe a little sex. But in the harsh light of the morning after, their worlds are thrown into a spin of confusion when hungover Sara accuses hard-partying Mike of date rape. Loyalties are tested as each among them is forced to take sides.

New York City. Melvin Udall, a cranky, bigoted, obsessive-compulsive writer, finds his life turned upside down when neighboring gay artist Simon is hospitalized and his dog is entrusted to Melvin. In addition, Carol, the only waitress who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.