James Bond must unmask the mysterious head of the Janus Syndicate and prevent the leader from utilizing the GoldenEye weapons system to inflict devastating revenge on Britain.

After escaping with Newt and Hicks from the alien planet, Ripley crash lands on Fiorina 161, a prison planet and host to a correctional facility. Unfortunately, although Newt and Hicks do not survive the crash, a more unwelcome visitor does. The prison does not allow weapons of any kind, and with aid being a long time away, the prisoners must simply survive in any way they can.

FBI Agent Will Graham, who retired after catching Hannibal Lecktor, returns to duty to engage in a risky cat-and-mouse game with Lecktor to capture a new killer.

After a mysterious explosion leaves a large fissure in the ground, two young boys are confronted by an unknown phenomenon that inflicts severe radiation burns on one of them. There follows a spate of attacks at radiation establishments as the inexplicable life-form plunders radium stores. Dr Royston, an expert in atomic research, is brought in to explain and curtail the activities of this alien creature before it causes disaster.