In the second installment of the Dhoom series, Jai and Ali are back as the buddy cops on their toughest job so far. “Mr.A” is an international thief who has planned to steal a priceless artifact in Mumbai and the police have got to nab him. But Mr.A manages to steal the artifact and elude the police. He finds his match in Sunehri and they form a partnership. They move on to Rio for their next job, with Jai and Ali hot on their trail. Mr.A whose actual name is Aryan, and Sunehri are drawn towards each other but little does Aryan know of Sunehri’s little secret.

A gang of bikers headed by the cool-headed and arrogant Kabir is on a robbing spree in Mumbai. They rob establishments and then zip away on their superbikes. ACP Jai Dixit is the case in-charge and he recruits a bumbling bike mechanic and racer named Ali to chase the gang on a bike and help Jai nab them. Kabir accepts the challenge, and pulls off another robbery amidst a function. This causes Jai and Ali to call it off. Jai resigns from the police force and Ali goes back to his daily job. Meanwhile Kabir has lost one of his team members and recruits Ali for their final job in Goa. The action shifts from the congested Mumbai traffic to the sunny Goa for the final showdown between cops and robbers.

Sanjay and Anjali are childhood chums . When Sanjay’s roommate Ria questions him whether he has fallen for Anjali he vehemently denies . But the truth that he indeed loves her hits him like a ton of bricks when Sanjana calls him to tell that she is getting married to Rohit. Sanjay wants to win Anjali’s heart at any cost and sets off on his “noble” cause of stopping the marriage.