While caring for his ailing wife, an American engineer in Pakistan stumbles upon a deadly pharmaceutical conspiracy.
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Three strangers arrive one by one to a mysterious cabin in the middle of nowhere after enduring separate life-altering predicaments. Searching for a way out of the woods, frustrated, hungry and battling to stay warm they discover their mysterious connection and realize what they have to do in order to get out of the woods alive.
Veteran spy Nathan Muir is on the verge of retiring from the CIA when he learns that his one-time protégé and close friend, Tom Bishop, is a political prisoner sentenced to die in Beijing. Although their friendship has been marred by bad blood and resentment, Muir agrees to take on the most dangerous mission of his career and rescue Bishop.
Returning to their family’s cabin in the dark, Wisconsin woods to scatter the ashes of their father, a troubled young man and his brash sister are terrorized by signs that an ancient, Native-American spirit, awakened by a ritual murder, has marked them for death.